Product Description

Factor Ba is the fragment of complement factor B that results from activation of the alternative pathway.CompTech prepares the factor Ba fragment from factor B which was purified from normal human serum.Complement factor B is a glycosylated protein composed of a single 93,000 Da polypeptide chain.Factor B is an essential component of the alternative pathway of complement activation and is found in plasma at approximately 200 µg/mL.In the presence of Mg⁺⁺ factor B binds to C3b and the C3b,B complex can be activated by factor D, a serine protease that circulates as an active trypsin-like serine protease.Cleavage of factor B by factor D causes the release of the Ba fragment (33,000 Da) and leaves the 60,000 Bb fragment bound to C3b.This Ba fragment comes from the N-terminal of factor B and it contains three CCP domains which interact with C3b (Morley, B.J. and Walport, M.J. (2000)). The isolated fragment Ba has been reported to have a weak affinity for C3b and to inhibit the interaction of factor B with C3b thus inhibiting the activation of the alternative pathway (Pryzdial, E.L. and Isenman, D.E., (1987)).

The fragments of factor B (Ba and Bb) have been proposed to elicit several biological responses.See the section titled Function below and in the product description for the Bb fragment.

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Complement Technology，Inc。（CompTech）致力于为生物医学研究界提供最高质量的补充试剂。CompTech的业主和员工在补充领域拥有超过80年的综合经验。我们是我们销售的补充试剂的原始制造商，我们努力成为最优质试剂的最低成本供应商。我们不断扩大我们生产的试剂系列，以满足不断变化的研究需求。我们欢迎您提供所需新试剂的建议。