Product Description

Normal human serum was depleted of factor H by immunoaffinity chromatography.The product is tested for the absence of factor H by double immunodiffusion. Factor H is a regulator of complement activation.As a result, factor H-Dpl is still capable of activating the alternative pathway and does so spontaneously and very rapidly in the absence of factor H.In fact, activation occurs in less than 2 min in the fluid phase without an activating particle resulting in the consumption of both C3 and factor B.For this reason this depleted serum is stored with 0.1 mM EDTA to inhibit spontaneous activation.Factor H-Dpl is certified to possess a functional alternative pathway for complement activation only if a controlling factor, such as factor H, is added prior to the addition of metal ions (specifically Mg⁺⁺).Full reconstitution requires addition of 500 µg factor H/mL serum.It is also tested for and certified to contain functional classical pathway indicating that all other complement components necessary for classical and alternative pathway activation are present except for factor H (Morgan, B.P. (2000); Dodds, A.W. and Sim, R.B. (1997)).

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Complement Technology，Inc。（CompTech）致力于为生物医学研究界提供最高质量的补充试剂。CompTech的业主和员工在补充领域拥有超过80年的综合经验。我们是我们销售的补充试剂的原始制造商，我们努力成为最优质试剂的最低成本供应商。我们不断扩大我们生产的试剂系列，以满足不断变化的研究需求。我们欢迎您提供所需新试剂的建议。