Product Description

The product C1s-C1INH Complex (CompTech#C1040) is made byinteracting purified protease inhibitor C1-INH (CompTech #A140) withpurified C1s enzyme (CompTech #A104) followed by purification. The protease inhibitor C1-INH prevents the spontaneous activation ofcomplement andlimits consumption of C2 and C4 by rapidly inactivatingC1r, C1s and MASP2. Itis the only plasma serine protease inhibitor(Serpin) capable of interactingwith and inhibiting activated C1.C1-INH interacts with the catalytic sites ofboth C1r and C1s. Theinteraction with activated C1r and C1s is covalentresulting incomplexes which are stable to SDS. C1s and C1r enzymes, however,areirreversibly inactivated by binding to C1-INH. C1s-C1INH (CompTech#C1040) isa very stable complex that remains intact even whensubjected to freeze/thawcycles with almost no loss of the complexform.

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Complement Technology，Inc。（CompTech）致力于为生物医学研究界提供最高质量的补充试剂。CompTech的业主和员工在补充领域拥有超过80年的综合经验。我们是我们销售的补充试剂的原始制造商，我们努力成为最优质试剂的最低成本供应商。我们不断扩大我们生产的试剂系列，以满足不断变化的研究需求。我们欢迎您提供所需新试剂的建议。