Product Description

C2 is central to the activation of both the classical and the lectin pathways of complement.It forms the proteolytic subunit of the C3 and C5 convertase of both pathways.Initiation of each pathway generates proteolytic enzyme complexes which are bound to the target surface (C1q/C1r/C1s in the classical pathway and MBL/ Ficolin/ MASPs in the lectin pathway).C1s and MASP in these complexes activate both C4 and C2.They cleave a peptide bond in C4 depositing C4b on the surface.They also cleave C2 into two fragments.The larger fragment (C2a) binds to C4b and forms the C3/C5 convertase enzyme complex C4b,C2a.This enzyme activates C3, deposits C3b on or near the C4b,C2a site and thus is converted from a weak C5 convertase to a highly efficient C5 convertase (C4b,C2a,C3b) with a K_m for C5 3000-fold lower than that of the C4b,C2a enzyme alone (Rawal N. and Pangburn M.K. (2003)).

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Complement Technology，Inc。（CompTech）致力于为生物医学研究界提供最高质量的补充试剂。CompTech的业主和员工在补充领域拥有超过80年的综合经验。我们是我们销售的补充试剂的原始制造商，我们努力成为最优质试剂的最低成本供应商。我们不断扩大我们生产的试剂系列，以满足不断变化的研究需求。我们欢迎您提供所需新试剂的建议。