Product Description

Normal human serum was depleted of factor P (properdin) by immunoaffinity chromatography.The product is tested for the absence of factor P by double immunodiffusion. Factor P is a positive regulator of alternative pathway complement activation.As a result, Factor P-Dpl is still capable of activating the alternative pathway but activation is slower than with properdin present.For example, lysis of rabbit erythrocytes by Factor P-Dpl requires 20-25 min to reach 50% without properdin, but with P added back or in NHS lysis requires only 5-7 min under otherwise identical conditions.Factor P-Dpl is certified to possess a functional alternative pathway for complement activation which is fully functional if reconstituted with properdin.Full reconstitution requires addition of 10 µg factor P/mL serum (Law, S.K.A. and Reid, K.B.M. (1995)).The normal human serum concentration of factor P has been variously reported to be between 4 and 20 µg/mL (Morley, B.J. and Walport, M.J. (2000); Morgan, B.P. (2000); Dodds, A.W. and Sim, R.B. (1997)).

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Complement Technology，Inc。（CompTech）致力于为生物医学研究界提供最高质量的补充试剂。CompTech的业主和员工在补充领域拥有超过80年的综合经验。我们是我们销售的补充试剂的原始制造商，我们努力成为最优质试剂的最低成本供应商。我们不断扩大我们生产的试剂系列，以满足不断变化的研究需求。我们欢迎您提供所需新试剂的建议。