Product Description

C1s depleted serum (C1s-Dpl) is normal human serum depleted of C1s byimmunoaffinity chromatography. The product is tested for the absence ofC1s by functional assays for classical pathway activity and for C1sprotein by double immunodiffusion. C1s-Dpl is certified to possess afunctional alternative pathway for complement activation (Morgan, B.P.(2000); Dodds, A.W. and Sim, R.B. (1997)).

In serumC1s is present in its proenzyme form (Valet, G and Cooper N.R. (1974);Ziccardi, R.J. and Cooper N.R. (1976)). C1s enzyme is the activated formof C1s proenzyme. C1s is a subunit of the C1 complex which is the firstcomponent in the classical pathway of complement (See productdescription for C1 Cat# A098). C1s proenzyme is an inactive zymogenuntil C1 is activated. C1r is activated when C1 binds to and isactivated by antibodies bound to antigens (immune complexes) yieldingC1r enzyme, the first protease that initiates the cascade. C1r enzyme inthe C1 complex activates C1s proenzyme generating C1s enzyme. Afunctional classical pathway can be reconstituted by addition ofpurified C1s proenzyme (31 µg/mL) to the C1s-Dpl indicating that allother complement components necessary for classical pathway activationare present and active.

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